Mutations in BRCA1/BARD1 RING-domain heterodimer
From Proteopedia
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To begin with scenes, please click the green link with the name of the mutation. | To begin with scenes, please click the green link with the name of the mutation. | ||
| + | *<scene name='75/751104/L22s/3'>Mutation L22S: </scene><jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. Putative new hydrogen bonds were added. | ||
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*<scene name='75/751104/L22s/3'>Mutation L22S: </scene><jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. Putative new hydrogen bonds were added. | *<scene name='75/751104/L22s/3'>Mutation L22S: </scene><jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. Putative new hydrogen bonds were added. | ||
Revision as of 12:06, 12 February 2017
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References
- ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833
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Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman
