Mutations in BRCA1/BARD1 RING-domain heterodimer

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==Benign mutations==
==Benign mutations==
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*'''Mutation K45Q:''' <scene name='75/751104/Cv/26'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/24'>Mutated and wildtype residues together</scene>. <scene name='75/751104/Cv/25'>Click here to see animation of this scene</scene>.
+
*<scene name='75/751104/Cv/26'>Mutation K45Q:</scene>
 +
<jmol>
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<jmolLink>
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<script>
 +
animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [LYS]45;color selectionHalos green;selectionHalos on;
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</script>
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<text>Wild type </text>
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</jmolLink>
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</jmol>
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conformation and
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<jmol>
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<jmolLink>
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<script>
 +
animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [GLN]45;color selectionHalos red;selectionHalos on;
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</script>
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<text>mutation.
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</text>
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</jmolLink>
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</jmol>
 +
Click here to see the
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<jmol>
 +
<jmolLink>
 +
<script>
 +
animation off; frame all; select [GLN]45;color selectionHalos red;selectionHalos on;
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</script>
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<text>mutated and wild type
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</text>
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</jmolLink>
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</jmol> residues together, and an
 +
<jmol>
 +
<jmolLink>
 +
<script>
 +
animation on; animation mode loop; frame play; select [GLN]45;color selectionHalos red;selectionHalos on;
 +
</script>
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<text>animation
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</text>
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</jmolLink>
 +
</jmol> between the two states.
*'''Mutation D67Y:''' <scene name='75/751104/Cv/27'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/11'>Mutated and wildtype residues together</scene>. <scene name='75/751104/Cv/10'>Click here to see animation of this scene</scene>.
*'''Mutation D67Y:''' <scene name='75/751104/Cv/27'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/11'>Mutated and wildtype residues together</scene>. <scene name='75/751104/Cv/10'>Click here to see animation of this scene</scene>.
</StructureSection>
</StructureSection>

Revision as of 09:38, 16 February 2017

PDB ID 1jm71.pdb

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References

  1. ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman

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