Mutations in Brca1 BRCT Domains

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</jmolLink>
</jmolLink>
</jmol> between the two states. In contrast to the pathogenic mutation G1706E, this mutation causes only slight overpacking.
</jmol> between the two states. In contrast to the pathogenic mutation G1706E, this mutation causes only slight overpacking.
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*<scene name='75/752201/T1720a/1'>Mutation T1720A:</scene>
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<jmol>
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<jmolLink>
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<script>
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animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [THR]1720;color selectionHalos green;selectionHalos on;
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</script>
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<text>Wild type </text>
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</jmolLink>
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</jmol>
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conformation and
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<jmol>
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<jmolLink>
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<script>
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animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [ALA]1720;color selectionHalos red;selectionHalos on;
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</script>
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<text>mutation.
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</text>
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</jmolLink>
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</jmol>
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Click here to see the
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<jmol>
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<jmolLink>
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<script>
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animation off; frame all; select [ALA]1720;color selectionHalos red;selectionHalos on;
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</script>
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<text>mutated and wild type
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</text>
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</jmolLink>
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</jmol> residues together, and an
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<jmol>
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<jmolLink>
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<script>
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animation on; animation mode loop; frame play; select [ALA]1720;color selectionHalos red;selectionHalos on;
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</script>
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<text>animation
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</text>
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</jmolLink>
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</jmol> between the two states. This mutation causes hydrogen bond lost.
</StructureSection>
</StructureSection>
== References ==
== References ==

Revision as of 10:32, 23 February 2017

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References

  1. ↑ Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9. PMID:15133502 doi:10.1038/nsmb775
  2. ↑ Williams RS, Glover JN. Structural consequences of a cancer-causing BRCA1-BRCT missense mutation. J Biol Chem. 2003 Jan 24;278(4):2630-5. Epub 2002 Nov 8. PMID:12427738 doi:10.1074/jbc.M210019200

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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