5g40
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g40 OCA], [http://pdbe.org/5g40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g40 RCSB], [http://www.ebi.ac.uk/pdbsum/5g40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g40 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g40 OCA], [http://pdbe.org/5g40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g40 RCSB], [http://www.ebi.ac.uk/pdbsum/5g40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g40 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | With early life likely to have existed in a hot environment, enzymes had to cope with an inherent drop in catalytic speed caused by lowered temperature. Here we characterize the molecular mechanisms underlying thermoadaptation of enzyme catalysis in adenylate kinase using ancestral sequence reconstruction spanning 3 billion years of evolution. We show that evolution solved the enzyme's key kinetic obstacle-how to maintain catalytic speed on a cooler Earth-by exploiting transition-state heat capacity. Tracing the evolution of enzyme activity and stability from the hot-start toward modern hyperthermophilic, mesophilic, and psychrophilic organisms illustrates active pressure versus passive drift in evolution on a molecular level, refutes the debated activity/stability trade-off, and suggests that the catalytic speed of adenylate kinase is an evolutionary driver for organismal fitness. | ||
| + | |||
| + | Evolutionary drivers of thermoadaptation in enzyme catalysis.,Nguyen V, Wilson C, Hoemberger M, Stiller JB, Agafonov RV, Kutter S, English J, Theobald DL, Kern D Science. 2017 Jan 20;355(6322):289-294. doi: 10.1126/science.aah3717. Epub 2016, Dec 22. PMID:28008087<ref>PMID:28008087</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5g40" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:59, 9 March 2017
Crystal structure of adenylate kinase ancestor 4 with Zn and AMP-ADP bound
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