1svf
From Proteopedia
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|PDB= 1svf |SIZE=350|CAPTION= <scene name='initialview01'>1svf</scene>, resolution 1.4Å | |PDB= 1svf |SIZE=350|CAPTION= <scene name='initialview01'>1svf</scene>, resolution 1.4Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
| - | |GENE= FUSION PROTEIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | |GENE= FUSION PROTEIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5]) |
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1svf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svf OCA], [http://www.ebi.ac.uk/pdbsum/1svf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1svf RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1SVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Simian_virus_5 Simian virus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVF OCA]. |
==Reference== | ==Reference== | ||
Structural basis for paramyxovirus-mediated membrane fusion., Baker KA, Dutch RE, Lamb RA, Jardetzky TS, Mol Cell. 1999 Mar;3(3):309-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10198633 10198633] | Structural basis for paramyxovirus-mediated membrane fusion., Baker KA, Dutch RE, Lamb RA, Jardetzky TS, Mol Cell. 1999 Mar;3(3):309-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10198633 10198633] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Simian virus | + | [[Category: Simian virus 5]] |
[[Category: Baker, K A.]] | [[Category: Baker, K A.]] | ||
[[Category: Dutch, R E.]] | [[Category: Dutch, R E.]] | ||
[[Category: Jardetzky, T S.]] | [[Category: Jardetzky, T S.]] | ||
[[Category: Lamb, R A.]] | [[Category: Lamb, R A.]] | ||
| - | [[Category: CL]] | ||
[[Category: coiled-coil]] | [[Category: coiled-coil]] | ||
[[Category: fusion]] | [[Category: fusion]] | ||
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[[Category: sv5]] | [[Category: sv5]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:34 2008'' |
Revision as of 20:47, 30 March 2008
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| , resolution 1.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | FUSION PROTEIN (Simian virus 5) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PARAMYXOVIRUS SV5 FUSION PROTEIN CORE
Overview
Paramyxoviruses are responsible for significant human mortality and disease worldwide, but the molecular mechanisms underlying their entry into host cells remain poorly understood. We have solved the crystal structure of a fragment of the simian parainfluenza virus 5 fusion protein (SV5 F), revealing a 96 A long coiled coil surrounded by three antiparallel helices. This structure places the fusion and transmembrane anchor of SV5 F in close proximity with a large intervening domain at the opposite end of the coiled coil. Six amino acids, potentially part of the fusion peptide, form a segment of the central coiled coil, suggesting that this structure extends into the membrane. Deletion mutants of SV5 F indicate that putative flexible tethers between the coiled coil and the viral membrane are dispensable for fusion. The lack of flexible tethers may couple a final conformational change in the F protein directly to the fusion of two bilayers.
About this Structure
1SVF is a Protein complex structure of sequences from Simian virus 5. Full crystallographic information is available from OCA.
Reference
Structural basis for paramyxovirus-mediated membrane fusion., Baker KA, Dutch RE, Lamb RA, Jardetzky TS, Mol Cell. 1999 Mar;3(3):309-19. PMID:10198633
Page seeded by OCA on Sun Mar 30 23:47:34 2008
