1t2s

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|PDB= 1t2s |SIZE=350|CAPTION= <scene name='initialview01'>1t2s</scene>
|PDB= 1t2s |SIZE=350|CAPTION= <scene name='initialview01'>1t2s</scene>
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1t2s|1T2S]], [[1upo|1UPO]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2s OCA], [http://www.ebi.ac.uk/pdbsum/1t2s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t2s RCSB]</span>
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[[Category: nucleic acid binding protein]]
[[Category: nucleic acid binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:26 2008''

Revision as of 20:50, 30 March 2008


PDB ID 1t2s

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Ligands: , ,
Related: 1T2S, 1UPO


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain


Overview

We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.

About this Structure

1T2S is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196

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