4ryx
From Proteopedia
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==Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form== | ==Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form== | ||
<StructureSection load='4ryx' size='340' side='right' caption='[[4ryx]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4ryx' size='340' side='right' caption='[[4ryx]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fsn|3fsn]], [[4rsc|4rsc]], [[4ryy|4ryy]], [[4ryz|4ryz]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fsn|3fsn]], [[4rsc|4rsc]], [[4ryy|4ryy]], [[4ryz|4ryz]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinoid_isomerohydrolase Retinoid isomerohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.64 3.1.1.64] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinoid_isomerohydrolase Retinoid isomerohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.64 3.1.1.64] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ryx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ryx RCSB], [http://www.ebi.ac.uk/pdbsum/4ryx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ryx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryx OCA], [http://pdbe.org/4ryx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ryx RCSB], [http://www.ebi.ac.uk/pdbsum/4ryx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ryx ProSAT]</span></td></tr> |
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | [[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | ||
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| + | ==See Also== | ||
| + | *[[Retinoid isomerohydrolase|Retinoid isomerohydrolase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 01:57, 10 March 2017
Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form
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