5f63
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the first bromodomain of human BRD4 in complex with SG3-179== | |
| - | + | <StructureSection load='5f63' size='340' side='right' caption='[[5f63]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5f63]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F63 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W2:4-[[4-[[3-(~{TERT}-BUTYLSULFONYLAMINO)-4-CHLORANYL-PHENYL]AMINO]-5-METHYL-PYRIMIDIN-2-YL]AMINO]-2-FLUORANYL-~{N}-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>5W2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f5z|5f5z]], [[5f60|5f60]], [[5f61|5f61]], [[5f62|5f62]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f63 OCA], [http://pdbe.org/5f63 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f63 RCSB], [http://www.ebi.ac.uk/pdbsum/5f63 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f63 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ember, S W]] | ||
| + | [[Category: Schonbrunn, E]] | ||
| + | [[Category: Zhu, J Y]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Cap]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Hunk1]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Mcap]] | ||
| + | [[Category: Mitotic chromosome associated protein]] | ||
| + | [[Category: Protein binding-inhibitor complex]] | ||
| + | [[Category: Transcription-inhibitor complex]] | ||
| + | [[Category: Transcription-transcription inhibitor complex]] | ||
Revision as of 09:22, 10 March 2017
Crystal structure of the first bromodomain of human BRD4 in complex with SG3-179
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