5tsr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3 magnesium transporter== | |
| - | + | <StructureSection load='5tsr' size='340' side='right' caption='[[5tsr]], [[Resolution|resolution]] 3.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tsr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TSR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tsr OCA], [http://pdbe.org/5tsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tsr RCSB], [http://www.ebi.ac.uk/pdbsum/5tsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tsr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref> [[http://www.uniprot.org/uniprot/CNNM3_HUMAN CNNM3_HUMAN]] Probable metal transporter. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Protein-tyrosine-phosphatase]] | ||
| + | [[Category: Gehring, K]] | ||
| + | [[Category: Kozlov, G]] | ||
| + | [[Category: Zhang, H]] | ||
| + | [[Category: Magnesium transporter]] | ||
| + | [[Category: Metal transport]] | ||
| + | [[Category: Phosphatase]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 09:28, 10 March 2017
Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3 magnesium transporter
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