5lfs

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m (Protected "5lfs" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5lfs is ON HOLD
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==Lambda-[Ru(bpy)2(dppz)]2+ bound to brominated DNA==
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<StructureSection load='5lfs' size='340' side='right' caption='[[5lfs]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lfs]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4izr 4izr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LFS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=R1Z:DELTA-[RU(BPY)2DPPZ]2+'>R1Z</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BT:5-BROMO-2-DEOXYCYTIDINE'>5BT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lfs OCA], [http://pdbe.org/5lfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lfs RCSB], [http://www.ebi.ac.uk/pdbsum/5lfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lfs ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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X-ray crystal structures of three Lambda-[Ru(L)2 dppz]2+ complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2'-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5'-CG-3' step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5'-TA-3' sites. This result suggests that canted intercalation is preferred at 5'-CG-3' sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5'-CG-3' step could give rise to a longer luminescence lifetime than canted intercalation.
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Authors: Hall, J.P., Cardin, C.J.
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Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.,Hall JP, Gurung SP, Henle J, Poidl P, Andersson J, Lincoln P, Winter G, Sorensen T, Cardin DJ, Brazier JA, Cardin CJ Chemistry. 2017 Jan 19. doi: 10.1002/chem.201605508. PMID:28105682<ref>PMID:28105682</ref>
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Description: Lambda-[Ru(bpy)2(dppz)]2+ bound to brominated DNA
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Hall, J.P]]
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<div class="pdbe-citations 5lfs" style="background-color:#fffaf0;"></div>
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[[Category: Cardin, C.J]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cardin, C J]]
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[[Category: Hall, J P]]
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[[Category: Dna]]
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[[Category: Intercalation]]
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[[Category: Light-switch]]
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[[Category: Ruthenium]]

Revision as of 17:26, 10 March 2017

Lambda-[Ru(bpy)2(dppz)]2+ bound to brominated DNA

5lfs, resolution 1.85Å

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