5mrc

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'''Unreleased structure'''
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{{Large structure}}
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==Structure of the yeast mitochondrial ribosome - Class A==
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<StructureSection load='5mrc' size='340' side='right' caption='[[5mrc]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5mrc]] is a 77 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MRC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyisobutyryl-CoA_hydrolase 3-hydroxyisobutyryl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.4 3.1.2.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrc OCA], [http://pdbe.org/5mrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrc RCSB], [http://www.ebi.ac.uk/pdbsum/5mrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrc ProSAT]</span></td></tr>
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</table>
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{{Large structure}}
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== Function ==
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[[http://www.uniprot.org/uniprot/RT23_YEAST RT23_YEAST]] Required for maintenance of mitochondrial DNA.<ref>PMID:11017876</ref> [[http://www.uniprot.org/uniprot/HIBCH_YEAST HIBCH_YEAST]] Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit.<ref>PMID:11378903</ref> <ref>PMID:14566057</ref> [[http://www.uniprot.org/uniprot/RTC6_YEAST RTC6_YEAST]] Probable component of the mitochondrial large ribosomal subunit involved in ribosome biogenesis and translation. May be involved in a process influencing telomere capping.<ref>PMID:9392081</ref> <ref>PMID:18845848</ref> <ref>PMID:20691087</ref> [[http://www.uniprot.org/uniprot/RT17_YEAST RT17_YEAST]] May have a meiosis-specific role as it accumulates during the middle stage of sporulation.<ref>PMID:15543521</ref> [[http://www.uniprot.org/uniprot/RT24_YEAST RT24_YEAST]] Involved in mitochondrial genome encoded proteins translation. [[http://www.uniprot.org/uniprot/RT10_YEAST RT10_YEAST]] Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity). [[http://www.uniprot.org/uniprot/RT12_YEAST RT12_YEAST]] Required for respiratory growth.<ref>PMID:11780787</ref> [[http://www.uniprot.org/uniprot/RSM28_YEAST RSM28_YEAST]] Involved in mitochondrial genome encoded proteins translation. [[http://www.uniprot.org/uniprot/MRP10_YEAST MRP10_YEAST]] Involved in mitochondrial genome encoded proteins translation.<ref>PMID:9065385</ref> [[http://www.uniprot.org/uniprot/COX24_YEAST COX24_YEAST]] Involved in the splicing of the COX1 mRNA.<ref>PMID:16339141</ref> [[http://www.uniprot.org/uniprot/FYV4_YEAST FYV4_YEAST]] Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin.<ref>PMID:12663529</ref> <ref>PMID:16552446</ref> [[http://www.uniprot.org/uniprot/MHR1_YEAST MHR1_YEAST]] Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells.<ref>PMID:11121487</ref> <ref>PMID:9736700</ref> <ref>PMID:7664749</ref> <ref>PMID:12198175</ref> <ref>PMID:12034822</ref> <ref>PMID:14565971</ref> <ref>PMID:16337661</ref> [[http://www.uniprot.org/uniprot/RM36_YEAST RM36_YEAST]] Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions.<ref>PMID:11259585</ref> <ref>PMID:15166137</ref> [[http://www.uniprot.org/uniprot/IMG1_YEAST IMG1_YEAST]] Essential for respiration.<ref>PMID:8771712</ref> [[http://www.uniprot.org/uniprot/RM06_YEAST RM06_YEAST]] Indispensable for mitochondrial function. [[http://www.uniprot.org/uniprot/RMAR_YEAST RMAR_YEAST]] Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.<ref>PMID:7770043</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we have determined the structure of the 75-component yeast mitoribosome to an overall resolution of 3.3 angstroms. The mitoribosomal small subunit has been built de novo and includes 15S ribosomal RNA (rRNA) and 34 proteins, including 14 without homologs in the evolutionarily related bacterial ribosome. Yeast-specific rRNA and protein elements, including the acquisition of a putatively active enzyme, give the mitoribosome a distinct architecture compared to the mammalian mitoribosome. At an expanded messenger RNA channel exit, there is a binding platform for translational activators that regulate translation in yeast but not mammalian mitochondria. The structure provides insights into the evolution and species-specific specialization of mitochondrial translation.
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The entry 5mrc is ON HOLD
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The structure of the yeast mitochondrial ribosome.,Desai N, Brown A, Amunts A, Ramakrishnan V Science. 2017 Feb 3;355(6324):528-531. doi: 10.1126/science.aal2415. PMID:28154081<ref>PMID:28154081</ref>
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Authors:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description:
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<div class="pdbe-citations 5mrc" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: 3-hydroxyisobutyryl-CoA hydrolase]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Amunts, A]]
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[[Category: Brown, A]]
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[[Category: Desai, N]]
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[[Category: Ramakrishnan, V]]
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[[Category: Mitochondrial]]
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[[Category: Ribosome]]
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[[Category: Yeast]]

Revision as of 17:48, 10 March 2017

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Structure of the yeast mitochondrial ribosome - Class A

5mrc, resolution 3.25Å

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