5x3l

Structural highlights

Function

[MYR1_MYRPI] Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, and also against the fungus C.albicans. Adopts an alpha-helical structure.^{[1] [2] [3]}

References

1. ↑ Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64. PMID:15639237 doi:http://dx.doi.org/10.1016/j.abb.2004.11.006
2. ↑ King MA, Wu QX, Donovan GR, Baldo BA. Flow cytometric analysis of cell killing by the jumper ant venom peptide pilosulin 1. Cytometry. 1998 Aug 1;32(4):268-73. PMID:9701394
3. ↑ Wu QX, King MA, Donovan GR, Alewood D, Alewood P, Sawyer WH, Baldo BA. Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula. Biochim Biophys Acta. 1998 Sep 16;1425(1):74-80. PMID:9813247