5m7e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tubulin-BKM120 complex== | |
| - | + | <StructureSection load='5m7e' size='340' side='right' caption='[[5m7e]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5m7e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M7E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SD5:5-[2,6-DI(MORPHOLIN-4-YL)PYRIMIDIN-4-YL]-4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE'>SD5</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o2b|4o2b]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7e OCA], [http://pdbe.org/5m7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7e RCSB], [http://www.ebi.ac.uk/pdbsum/5m7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7e ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
[[Category: Bohnacker, T]] | [[Category: Bohnacker, T]] | ||
| - | [[Category: Steinmetz, M | + | [[Category: Prota, A E]] |
| - | [[Category: Wymann, M | + | [[Category: Steinmetz, M O]] |
| + | [[Category: Wymann, M P]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Cytoskeleton]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Tubulin fold]] | ||
Revision as of 01:38, 11 March 2017
Tubulin-BKM120 complex
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