5tik
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA== | |
| + | <StructureSection load='5tik' size='340' side='right' caption='[[5tik]], [[Resolution|resolution]] 3.09Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5tik]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIK FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tih|5tih]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tik OCA], [http://pdbe.org/5tik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tik RCSB], [http://www.ebi.ac.uk/pdbsum/5tik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tik ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of erythrocytes by merozoites, in which they grow and divide to release daughter merozoites, which in turn invade new erythrocytes perpetuating the cycle responsible for malaria. A key step in merozoite invasion is the essential binding of PfRh5/CyRPA/PfRipr complex to basigin, a step linked to formation of a pore between merozoites and erythrocytes. We show CyRPA interacts directly with PfRh5. An invasion inhibitory monoclonal antibody to CyRPA blocks binding of CyRPA to PfRh5 and complex formation thus illuminating the molecular mechanism for inhibition of parasite growth. We determined the crystal structures of CyRPA alone and in complex with antibody Fab fragment. CyRPA has a six-bladed beta-propeller fold, and we identify the region that interacts with PfRh5. This functionally conserved epitope is a potential target for vaccines against P. falciparum. | ||
| - | + | Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.,Chen L, Xu Y, Wong W, Thompson JK, Healer J, Goddard-Borger E, Lawrence MC, Cowman AF Elife. 2017 Feb 14;6. pii: e21347. doi: 10.7554/eLife.21347. PMID:28195530<ref>PMID:28195530</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 5tik" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, L]] | ||
| + | [[Category: Cowman, A F]] | ||
[[Category: Goddard-Borger, E]] | [[Category: Goddard-Borger, E]] | ||
| - | [[Category: Thompson, J | + | [[Category: Lawrence, M C]] |
| + | [[Category: Thompson, J K]] | ||
[[Category: Wang, W]] | [[Category: Wang, W]] | ||
| - | [[Category: | + | [[Category: Xu, Y]] |
| - | [[Category: | + | [[Category: Immune system]] |
| + | [[Category: Plasmodium falciparum cyrpa inhibitory antibody]] | ||
Revision as of 09:40, 11 March 2017
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
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