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| - | | + | #REDIRECT [[5upd]] This PDB entry is obsolete and replaced by 5upd |
| - | ==Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)==
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| - | <StructureSection load='4yz8' size='340' side='right' caption='[[4yz8]], [[Resolution|resolution]] 1.80Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4yz8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZ8 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz8 OCA], [http://pdbe.org/4yz8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yz8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yz8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yz8 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>
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| - | ==See Also==
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| - | *[[Histone methyltransferase|Histone methyltransferase]]
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Histone-lysine N-methyltransferase]]
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| - | [[Category: Arrowsmith, C H]]
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| - | [[Category: Bountra, C]]
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| - | [[Category: Brown, P J]]
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| - | [[Category: Cerovina, T]]
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| - | [[Category: Dong, A]]
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| - | [[Category: Edwards, A M]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Tempel, W]]
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| - | [[Category: Wu, H]]
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| - | [[Category: Yu, W]]
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| - | [[Category: Methyl transferase]]
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| - | [[Category: Sgc]]
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| - | [[Category: Transferase]]
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