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| - | | + | #REDIRECT [[5mjv]] This PDB entry is obsolete and replaced by 5mjv |
| - | ==Rebuild and re-refined model for Human Parechovirus 1==
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| - | <StructureSection load='5m74' size='340' side='right' caption='[[5m74]], [[Resolution|resolution]] 3.09Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5m74]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_22_(strain_harris) Echovirus 22 (strain harris)] and [http://en.wikipedia.org/wiki/Human_parechovirus_1_(strain_harris) Human parechovirus 1 (strain harris)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M74 FirstGlance]. <br>
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| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z92|4z92]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m74 OCA], [http://pdbe.org/5m74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m74 RCSB], [http://www.ebi.ac.uk/pdbsum/5m74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m74 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/POLG_HPE1H POLG_HPE1H]] Capsid proteins VP0, VP2, VP3 form a closed capsid enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:11160695</ref> Protein 2A: Is not a protease. Protein 2B: Affects membrane integrity and cause an increase in membrane permeability. Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity). Protein 3A, via its hydrophobic domain, serves as membrane anchor. Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity). RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[PROSITE-ProRule:PRU00539]
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Butcher, S J]]
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| - | [[Category: Cockburn, J J.B]]
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| - | [[Category: Dykeman, E C]]
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| - | [[Category: Ora, A]]
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| - | [[Category: Shakeel, S]]
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| - | [[Category: Stockley, P G]]
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| - | [[Category: Twarock, R]]
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| - | [[Category: White, S J]]
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| - | [[Category: Hpev]]
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| - | [[Category: Hpev1]]
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| - | [[Category: Human parechovirus 1]]
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| - | [[Category: Parechovirus]]
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| - | [[Category: Picornavirus]]
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| - | [[Category: Rna]]
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| - | [[Category: Virus]]
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