5i7p
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD== | |
| - | + | <StructureSection load='5i7p' size='340' side='right' caption='[[5i7p]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i7p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I7P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7p OCA], [http://pdbe.org/5i7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i7p RCSB], [http://www.ebi.ac.uk/pdbsum/5i7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7p ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dobbek, H]] | ||
| + | [[Category: Jakob, R P]] | ||
| + | [[Category: Knappe, T A]] | ||
| + | [[Category: Schmid, F X]] | ||
| + | [[Category: Insert in flap]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Chimeric protein]] | ||
| + | [[Category: Fkbp12]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Prolyl isomerization]] | ||
| + | [[Category: Protein design]] | ||
| + | [[Category: Slyd]] | ||
Revision as of 19:12, 11 March 2017
Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD
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