5i6j
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of SRGAP2 F-BARx== | |
| - | + | <StructureSection load='5i6j' size='340' side='right' caption='[[5i6j]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i6j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I6J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6j OCA], [http://pdbe.org/5i6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i6j RCSB], [http://www.ebi.ac.uk/pdbsum/5i6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i6j ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13). | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Guez-Haddad, J]] | ||
| + | [[Category: Isupov, M N]] | ||
| + | [[Category: Opatowsky, Y]] | ||
| + | [[Category: Sporny, M]] | ||
| + | [[Category: F-bar]] | ||
| + | [[Category: Fx]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Srgap2]] | ||
Revision as of 19:12, 11 March 2017
Crystal Structure of SRGAP2 F-BARx
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Categories: Guez-Haddad, J | Isupov, M N | Opatowsky, Y | Sporny, M | F-bar | Fx | Signaling protein | Srgap2
