Sandbox Reserved 1061

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=== Active State ===
=== Active State ===
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Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of '''TEVD'''. The protein then becomes a Tetramer of Dimers.
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Originally it was thought to be cleaved and activated by a combination of Caspases-3 and -7, but research has shown that Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of '''TEVD'''. The protein then becomes a Tetramer of Dimers.
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<scene name='69/694228/Activated_protein/1'> Activated Caspase-6 </scene>Text To Be Displayed</scene>[[Image:Caspase_6.jpg|100 px|left|thumb|Figure Legend]]
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<scene name='69/694228/Activated_protein/1'> Activated Caspase-6 </scene> this shows the protein bound [[Image:Caspase_6.jpg|100 px|left|thumb|Figure Legend]]
== Mechanism of Action ==
== Mechanism of Action ==
Mechanism is unknown as of right now. The active sight is known to be HIS-121, CYS-163, and GLU-174. It is tightly regulated by Zinc binding to an allosteric site.
Mechanism is unknown as of right now. The active sight is known to be HIS-121, CYS-163, and GLU-174. It is tightly regulated by Zinc binding to an allosteric site.
== Zinc Ligand(s) ==
== Zinc Ligand(s) ==
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The Zinc ligand is known to inhibit the
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The Zinc ligand is known to inhibit the Caspase-6 protein.
== Other Ligands ==
== Other Ligands ==
Other ligands that bind to Caspase-6 are caspase-8, which is activated within the caspase-chain by Caspase 6. After it being activated by Caspase-6, Caspase-8 is then in it's active state. Caspase-6 has been know to be a self-activator, so other Caspase-6 proteins are also known to be ligands that are bound at the active site.
Other ligands that bind to Caspase-6 are caspase-8, which is activated within the caspase-chain by Caspase 6. After it being activated by Caspase-6, Caspase-8 is then in it's active state. Caspase-6 has been know to be a self-activator, so other Caspase-6 proteins are also known to be ligands that are bound at the active site.

Revision as of 13:17, 14 March 2017

Text To Be Displayed</scene>
Figure Legend
Figure Legend
This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
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Human Caspase-6

Caspase-6

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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