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Biological Function

Czr A is a transcriptional repressor protein responsible for the regulation of the Chromosome Determined Zinc Responsible (Czr) operon. The Czr operon contains genes for the proteins Czr A and Czr B. Czr B is a Zinc transport protein which moves Zinc out of a cell. Czr A regulates this process by controlling the degree to which Czr B is expressed. When relatively low amounts of zinc are present in the cell Czr A will bind to DNA, inhibiting expression of Czr B, enabling the cell to retain Zinc. When high amounts of Zinc 2+ are present in the cell, each Czr A molecule binds two Zn 2+ ions, and forcing a conformational change. The zinc binding conformation of Czr A is not capable of binding to DNA, as the new conformation disrupts the DNA binding pocket. Conversely, the DNA binding conformation of Czr A does not allow for the binding of either Zn 2+ atom.

Structural Overview

DNA Binding

Zinc Binding

Zinc Ligand(s)

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References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644