This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Biological Function
Czr A is a transcriptional repressor protein responsible for the regulation of the Chromosome Determined Zinc Responsible (Czr) operon. The Czr operon contains genes for the proteins Czr A and Czr B. Czr B is a Zinc transport protein which moves Zn 2+ out of a cell. Czr A regulates this process by controlling the degree to which Czr B is expressed. When relatively low amounts of zinc are present in the cell Czr A will bind to DNA,preventing the progression of RNA polymerase and thus inhibiting expression of Czr B. Decreased expression of Czr B results in the ability of the cell to retain Zn 2+ more readily. Because Czr A and Czr B are transcribed as part of the same operon, there must be a way that Czr A is inhibited to allow full transcription of Czr B. Czr A is inhibited by the binding of two Zn 2+ ions, which is ideal considering that this mechanism allows for Zn 2+ concentration inside the cell to determine the need for Zn 2+ transport out of the cell. Zn 2+ competitively inhibits the binding of DNA to Czr A. Czr A has two distinct conformations, one of which binds Zn 2+ with very high affinity that has virtually no affinity towards DNA binding, the other having a high affinity for DNA binding but very little affinity for Zn 2+.
DNA Binding
Zinc Binding
Zinc Ligand(s)
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
