1tif
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1tif |SIZE=350|CAPTION= <scene name='initialview01'>1tif</scene>, resolution 1.8Å | |PDB= 1tif |SIZE=350|CAPTION= <scene name='initialview01'>1tif</scene>, resolution 1.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PBM:TRIMETHYL+LEAD+ION'>PBM</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]) | |GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tif OCA], [http://www.ebi.ac.uk/pdbsum/1tif PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tif RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Ramakrishnan, V.]] | [[Category: Ramakrishnan, V.]] | ||
[[Category: Shu, F.]] | [[Category: Shu, F.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: PBM]] | ||
[[Category: if3 n-terminal domain]] | [[Category: if3 n-terminal domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:30 2008'' |
Revision as of 20:56, 30 March 2008
| |||||||
| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | T7 (Geobacillus stearothermophilus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN
Overview
The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor.
About this Structure
1TIF is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix., Biou V, Shu F, Ramakrishnan V, EMBO J. 1995 Aug 15;14(16):4056-64. PMID:7664745
Page seeded by OCA on Sun Mar 30 23:56:30 2008
