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5x61
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A== | |
| + | <StructureSection load='5x61' size='340' side='right' caption='[[5x61]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5x61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X61 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x61 OCA], [http://pdbe.org/5x61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x61 RCSB], [http://www.ebi.ac.uk/pdbsum/5x61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x61 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACES_ANOGA ACES_ANOGA]] Rapidly hydrolyzes choline released into the synapse. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Acetylcholinesterase (AChE) hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses in the central nervous system (Toutant, 1989). Inhibition of the enzyme in insects could lead to the death of insects rapidly; thus AChE has been a molecular target for developing insecticides. This article is protected by copyright. All rights reserved. | ||
| - | + | Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae.,Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J Insect Sci. 2017 Mar 1. doi: 10.1111/1744-7917.12450. PMID:28247978<ref>PMID:28247978</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5x61" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: Carlier, P | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| + | [[Category: Acetylcholinesterase]] | ||
| + | [[Category: Carlier, P R]] | ||
[[Category: Ding, H]] | [[Category: Ding, H]] | ||
| - | [[Category: Wong, D.M]] | ||
[[Category: Han, Q]] | [[Category: Han, Q]] | ||
| + | [[Category: Lam, P C.H]] | ||
| + | [[Category: Li, J]] | ||
| + | [[Category: Robinson, H]] | ||
| + | [[Category: Totrov, M M]] | ||
| + | [[Category: Wong, D M]] | ||
| + | [[Category: Alpha/beta hydrolase fold]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 21:11, 15 March 2017
Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A
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