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5irq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel== | |
| - | + | <StructureSection load='5irq' size='340' side='right' caption='[[5irq]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5irq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6D7:(R)-ORTERONEL'>6D7</scene>, <scene name='pdbligand=7D6:(S)-ORTERONEL'>7D6</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5irv|5irv]]</td></tr> |
| - | [[Category: Petrunak, E | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5irq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irq OCA], [http://pdbe.org/5irq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5irq RCSB], [http://www.ebi.ac.uk/pdbsum/5irq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5irq ProSAT]</span></td></tr> |
| - | [[Category: Scott, E | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Petrunak, E M]] | ||
| + | [[Category: Scott, E E]] | ||
| + | [[Category: Inhibitor complex]] | ||
| + | [[Category: Lyase-inhibitor complex]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 21:18, 15 March 2017
Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel
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