This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5pi2
From Proteopedia
(Difference between revisions)
m (Protected "5pi2" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of JMJD2D after initial refinement with no ligand modelled (structure 15)== | |
| - | + | <StructureSection load='5pi2' size='340' side='right' caption='[[5pi2]], [[Resolution|resolution]] 1.52Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5pi2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PI2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pi2 OCA], [http://pdbe.org/5pi2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pi2 RCSB], [http://www.ebi.ac.uk/pdbsum/5pi2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pi2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bradley, A R]] | ||
| + | [[Category: Brandao-Neto, J]] | ||
| + | [[Category: Brennan, P E]] | ||
| + | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Collins, P]] | ||
| + | [[Category: Cox, O]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Dias, A]] | ||
| + | [[Category: Douangamath, A]] | ||
| + | [[Category: Edwards, A]] | ||
| + | [[Category: Fairhead, M]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| + | [[Category: MacLean, E]] | ||
| + | [[Category: Ng, J]] | ||
| + | [[Category: Oppermann, U]] | ||
| + | [[Category: Pearce, N M]] | ||
| + | [[Category: Renjie, Z]] | ||
| + | [[Category: Sethi, R]] | ||
| + | [[Category: Szykowska, A]] | ||
| + | [[Category: Talon, R]] | ||
| + | [[Category: Vollmar, M]] | ||
| + | [[Category: Wright, N]] | ||
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Jmj domain]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Pandda]] | ||
| + | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
Revision as of 21:25, 15 March 2017
PanDDA analysis group deposition -- Crystal Structure of JMJD2D after initial refinement with no ligand modelled (structure 15)
| |||||||||||
Categories: Arrowsmith, C H | Bountra, C | Bradley, A R | Brandao-Neto, J | Brennan, P E | Burgess-Brown, N | Collins, P | Cox, O | Delft, F von | Dias, A | Douangamath, A | Edwards, A | Fairhead, M | Krojer, T | MacLean, E | Ng, J | Oppermann, U | Pearce, N M | Renjie, Z | Sethi, R | Szykowska, A | Talon, R | Vollmar, M | Wright, N | Epigenetic | Jmj domain | Oxidoreductase | Pandda | Sgc - diamond i04-1 fragment screening
