5pwd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of SP100 in complex with N09600b== | |
| - | + | <StructureSection load='5pwd' size='340' side='right' caption='[[5pwd]], [[Resolution|resolution]] 1.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5pwd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PWD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=81P:4-(METHYLAMINO)BENZOIC+ACID'>81P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pwd OCA], [http://pdbe.org/5pwd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pwd RCSB], [http://www.ebi.ac.uk/pdbsum/5pwd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pwd ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN]] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bradley, A R]] | ||
| + | [[Category: Brandao-Neto, J]] | ||
| + | [[Category: Brennan, P E]] | ||
| + | [[Category: Collins, P]] | ||
| + | [[Category: Cox, O]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Dias, A]] | ||
| + | [[Category: Douangamath, A]] | ||
| + | [[Category: Edwards, A]] | ||
| + | [[Category: Fairhead, M]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| + | [[Category: MacLean, E]] | ||
| + | [[Category: Ng, J]] | ||
| + | [[Category: Pearce, N M]] | ||
| + | [[Category: Renjie, Z]] | ||
| + | [[Category: Sethi, R]] | ||
| + | [[Category: Talon, R]] | ||
| + | [[Category: Wright, N]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Pandda]] | ||
| + | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Xchemexplorer]] | ||
Revision as of 21:46, 15 March 2017
PanDDA analysis group deposition -- Crystal Structure of SP100 in complex with N09600b
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Categories: Arrowsmith, C H | Bountra, C | Bradley, A R | Brandao-Neto, J | Brennan, P E | Collins, P | Cox, O | Delft, F von | Dias, A | Douangamath, A | Edwards, A | Fairhead, M | Krojer, T | MacLean, E | Ng, J | Pearce, N M | Renjie, Z | Sethi, R | Talon, R | Wright, N | Bromodomain | Epigenetic | Pandda | Sgc - diamond i04-1 fragment screening | Transcription | Xchemexplorer
