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5tz1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1)== | |
| - | + | <StructureSection load='5tz1' size='340' side='right' caption='[[5tz1]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tz1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TZ1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VT1:(R)-2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-3-(1H-TETRAZOL-1-YL)-1-(5-(4-(2,2,2-TRIFLUOROETHOXY)PHENYL)PYRIDIN-2-YL)PROPAN-2-OL'>VT1</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fsa|5fsa]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tz1 OCA], [http://pdbe.org/5tz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tz1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tz1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sterol 14-demethylase]] | ||
| + | [[Category: Hargrove, T]] | ||
| + | [[Category: Lepesheva, G]] | ||
[[Category: Wawrzak, Z]] | [[Category: Wawrzak, Z]] | ||
| - | [[Category: | + | [[Category: Cyp51]] |
| - | [[Category: | + | [[Category: Cytochrome p450]] |
| + | [[Category: Cytochrome p450 fold]] | ||
| + | [[Category: Endoplasmic reticulum membrane]] | ||
| + | [[Category: Eukaryotic membrane]] | ||
| + | [[Category: Heme]] | ||
| + | [[Category: Monooxygenase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
| + | [[Category: Sterol biosynthesis]] | ||
Revision as of 21:47, 15 March 2017
Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1)
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