1tow

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|PDB= 1tow |SIZE=350|CAPTION= <scene name='initialview01'>1tow</scene>, resolution 2.00&Aring;
|PDB= 1tow |SIZE=350|CAPTION= <scene name='initialview01'>1tow</scene>, resolution 2.00&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC ACID'>CRZ</scene>
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|LIGAND= <scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC+ACID'>CRZ</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1tou|1TOU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tow OCA], [http://www.ebi.ac.uk/pdbsum/1tow PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tow RCSB]</span>
}}
}}
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[[Category: Svensson, S.]]
[[Category: Svensson, S.]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg, J.]]
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[[Category: CRZ]]
 
[[Category: lipid-binding]]
[[Category: lipid-binding]]
[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:05 2008''

Revision as of 20:59, 30 March 2008

Image:1tow.gif


PDB ID 1tow

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Related: 1TOU


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand


Overview

Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.

About this Structure

1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969

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