User:Jessica Klingensmith/Sandbox 1068
From Proteopedia
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==Zinc Transporter YiiP== 2 | ==Zinc Transporter YiiP== 2 | ||
| + | == Introduction == | ||
| + | Zinc transporter YiiP is an integral membrane protein found in the membrane of Esherichia coli. YiiP is a member of the cation diffusion facilitator family (LINK). Members of this family occur all throughout the biological realm. These diffusion facilitators export divalent transition metal ions from the cytoplasm to the extracellular space (CITE https://www.bnl.gov/isd/documents/71335.pdf). They work to regulate the amount of divalent metals inside of the cell, which is biologically relevant because while these metals are necessary for different biological functions, they can prove fatal to the cell in excess amounts. Zinc is essential for the growth and development of cells and zinc levels can affect everything from gene expression to immune response. Zinc transporters help keep homeostatic balance of zinc in cells and excessive zinc concentrations have been noted in cases of high beta-amyloid deposition contributing to Alzheimer's disease (CITE: http://science.sciencemag.org/content/317/5845/1746.full While YiiP is an integral membrane protein in the cells of Escherichia coli, understanding the mechanism of regulation behind it can help researcher's better understand the CDF equivalents in eukaryotic cells. | ||
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page '''Jessica Klingensmith/Sandbox 1068'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Jessica Klingensmith/Sandbox 1068'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == Introduction == | ||
| - | Zinc transporter YiiP is an integral membrane protein found in the membrane of Esherichia coli. YiiP is a member of the cation diffusion facilitator family (LINK). Members of this family occur all throughout the biological realm. These diffusion facilitators export divalent transition metal ions from the cytoplasm to the extracellular space (CITE https://www.bnl.gov/isd/documents/71335.pdf). They work to regulate the amount of divalent metals inside of the cell, which is biologically relevant because while these metals are necessary for different biological functions, they can prove fatal to the cell in excess amounts. Zinc is essential for the growth and development of cells and zinc levels can affect everything from gene expression to immune response. Zinc transporters help keep homeostatic balance of zinc in cells and excessive zinc concentrations have been noted in cases of high beta-amyloid deposition contributing to Alzheimer's disease (CITE: http://science.sciencemag.org/content/317/5845/1746.full While YiiP is an integral membrane protein in the cells of Escherichia coli, understanding the mechanism of regulation behind it can help researcher's better understand the CDF equivalents in eukaryotic cells. | ||
== Structure == | == Structure == | ||
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===Interlocking Salt Bridge=== | ===Interlocking Salt Bridge=== | ||
| - | The salt bridge formation between Lys77 and Asp207 of each domain of YiiP form an interlocking salt bridge | + | The salt bridge formation between Lys77 and Asp207 of each domain of YiiP form an interlocking salt bridge that acts as the pivot point of the conformational change that drives the function of YiiP. When the salt bridge is broken via.... the conformational change occurs, driving zinc out of the cell. This salt bridge also aids in holding the two protomers together. [[Image:Saltbridge.png|200px|left|thumb|Lys77 and Asp207 Salt Bridges]] |
===Active Sites=== | ===Active Sites=== | ||
Revision as of 18:48, 17 March 2017
==Zinc Transporter YiiP== 2
Introduction
Zinc transporter YiiP is an integral membrane protein found in the membrane of Esherichia coli. YiiP is a member of the cation diffusion facilitator family (LINK). Members of this family occur all throughout the biological realm. These diffusion facilitators export divalent transition metal ions from the cytoplasm to the extracellular space (CITE https://www.bnl.gov/isd/documents/71335.pdf). They work to regulate the amount of divalent metals inside of the cell, which is biologically relevant because while these metals are necessary for different biological functions, they can prove fatal to the cell in excess amounts. Zinc is essential for the growth and development of cells and zinc levels can affect everything from gene expression to immune response. Zinc transporters help keep homeostatic balance of zinc in cells and excessive zinc concentrations have been noted in cases of high beta-amyloid deposition contributing to Alzheimer's disease (CITE: http://science.sciencemag.org/content/317/5845/1746.full While YiiP is an integral membrane protein in the cells of Escherichia coli, understanding the mechanism of regulation behind it can help researcher's better understand the CDF equivalents in eukaryotic cells.
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
