Calcium/Calmodulin-dependent protein kinase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | [[Ca2+/Calmodulin dependent protein kinase]] (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br /> | + | [[Ca2+/Calmodulin dependent protein kinase]] (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br /> |
*'''CaMKI''' is a specialized CaM kinase.<br /> | *'''CaMKI''' is a specialized CaM kinase.<br /> | ||
*'''CaMKII''' is multifunctional kinase. <br /> | *'''CaMKII''' is multifunctional kinase. <br /> | ||
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**[[1a06]] – rCaMK - rat<br /> | **[[1a06]] – rCaMK - rat<br /> | ||
| - | **[[3nyv]], [[3n51]], [[3i7b]], [[3i7c]], [[3hzt]] – TgCaMK + inhibitor – ''Toxoplasma gondii''<br /> | ||
| - | **[[3ku2]], [[3i79]] - TgCaMK <br /> | ||
| - | **[[3khe]] – TgCaMK residues 345-535 + Ca<br /> | ||
| - | **[[3hx4]] – TgCaMK+Ca<br /> | ||
| - | **[[3dxn]], [[3is5]] – TgCaMK kinase domain + Ca<br /> | ||
| - | **[[3mwu]] – CpCaMK (mutant)+ inhibitor + Ca – ''Cryptosporidium parvum''<br /> | ||
| - | **[[3ncg]] - CpCaMK + inhibitor + Ca <br /> | ||
| - | **[[3igo]] - CpCaMK +Ca <br /> | ||
| - | **[[3hko]] - CpCaMK kinase domain residues 125-452 + Zn<br /> | ||
| - | **[[2qg5]], [[3dfa]] – CpCaMK kinase domain<br /> | ||
| - | **[[3f3z]] – CpCaMK kinase domain+indirubin_E804<br /> | ||
| - | **[[2aao]] – CaMK C terminal + Ca – ''Arabidopsis thaliana''<br /> | ||
| - | **[[1s6j]], [[1s6i]] – sCaMK α residues 329-402 + Ca – soybean - NMR<br /> | ||
**[[2jam]] - hCaMKI kinase domain +peptides - human<br /> | **[[2jam]] - hCaMKI kinase domain +peptides - human<br /> | ||
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**[[1hkx]] - mCaMKII α - mouse<br /> | **[[1hkx]] - mCaMKII α - mouse<br /> | ||
**[[3gp2]] – cCaMKII δ +CaM – chicken<br /> | **[[3gp2]] – cCaMKII δ +CaM – chicken<br /> | ||
| - | **[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br /> | ||
| - | **[[3kl8]] – CeCaMKII (mutant)+inhibitor<br /> | ||
| - | **[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br /> | ||
| - | **[[3pm8]] – PfCaMKII CBD + Ca – ''Plasmodium falciparum'' <br /> | ||
| - | **[[4mvf]] – PfCaMKII + Ca + staurosporine <br /> | ||
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| - | *CaMKIII | ||
| - | |||
| - | **[[3lij]] – CpCaMKIII +Ca<br /> | ||
| - | **[[3l19]], [[3hko]] – CpCaMKIII CBD + Ca<br /> | ||
| - | **[[3k21]] – PfCaMKIII C terminal + Ca <br /> | ||
| - | **[[3jwq]] – CaMKIII C terminal + Ca – ''Plasmodium berhei'' <br /> | ||
| - | **[[3o4y]] – CaMKIII C terminal + Ca – ''Plasmodium vivax'' <br /> | ||
* CaMKIV | * CaMKIV | ||
**[[2w4o]] – hCaMKIV+inhibitor<br /> | **[[2w4o]] – hCaMKIV+inhibitor<br /> | ||
| - | **[[4rgj]] – PfCaMKIV <br /> | ||
| - | **[[4qox]] – PfCaMKIV + Mg <br /> | ||
}} | }} | ||
Revision as of 10:41, 22 March 2017
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3D Structures of Ca2+/Calmodulin dependent protein kinase
Updated on 22-March-2017
References
- ↑ Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654 doi:10.1371/journal.pbio.1000426
See Calcium-dependent protein kinase
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky
