5bjt

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'''Unreleased structure'''
 
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The entry 5bjt is ON HOLD until Paper Publication
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==Crystal structure of human FcRn with a peptide inhibitor at multiple sites==
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<StructureSection load='5bjt' size='340' side='right' caption='[[5bjt]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bjt]] is a 15 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BJT FirstGlance]. <br>
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Description:
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m17|3m17]], [[3m1b|3m1b]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bjt OCA], [http://pdbe.org/5bjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bjt RCSB], [http://www.ebi.ac.uk/pdbsum/5bjt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bjt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/FCGRN_HUMAN FCGRN_HUMAN]] Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Badger, J]]
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[[Category: Nienaber, V]]
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[[Category: Amyloid]]
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[[Category: Amyloidosis]]
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[[Category: Cell membrane]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycation]]
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[[Category: Glycoprotein]]
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[[Category: Igg-binding protein]]
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[[Category: Immune response]]
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[[Category: Immune system-inhibitor complex]]
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[[Category: Immunoglobulin binding protein]]
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[[Category: Immunoglobulin domain]]
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[[Category: Mhc i]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Transmembrane]]

Revision as of 16:19, 22 March 2017

Crystal structure of human FcRn with a peptide inhibitor at multiple sites

5bjt, resolution 3.20Å

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