1tqi
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= RIO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 Archaeoglobus fulgidus DSM 4304]) | |GENE= RIO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 Archaeoglobus fulgidus DSM 4304]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1tqm|1TQM]], [[1tqp|1TQP]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqi OCA], [http://www.ebi.ac.uk/pdbsum/1tqi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tqi RCSB]</span> | ||
}} | }} | ||
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[[Category: LaRonde-LeBlanc, N.]] | [[Category: LaRonde-LeBlanc, N.]] | ||
[[Category: Wlodawer, A.]] | [[Category: Wlodawer, A.]] | ||
| - | [[Category: EDO]] | ||
[[Category: serine kinase]] | [[Category: serine kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:41 2008'' |
Revision as of 20:59, 30 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | RIO2 (Archaeoglobus fulgidus DSM 4304) | ||||||
| Related: | 1TQM, 1TQP
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase
Overview
The RIO family of atypical serine/threonine kinases contains two subfamilies, Rio1 and Rio2, highly conserved from archaea to man. Both RIO proteins from Saccharomyces cerevisiae catalyze serine phosphorylation in vitro, and the presence of conserved catalytic residues is required for cell viability. The activity of Rio2 is necessary for rRNA cleavage in 40S ribosomal subunit maturation. We solved the X-ray crystal structure of Archaeoglobus fulgidus Rio2, with and without bound nucleotides, at 2.0 A resolution. The C-terminal RIO domain is indeed structurally homologous to protein kinases, although it differs from known serine kinases in ATP binding and lacks the regions important for substrate binding. Unexpectedly, the N-terminal Rio2-specific domain contains a winged helix fold, seen primarily in DNA-binding proteins. These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases.
About this Structure
1TQI is a Single protein structure of sequence from Archaeoglobus fulgidus dsm 4304. Full crystallographic information is available from OCA.
Reference
Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases., LaRonde-LeBlanc N, Wlodawer A, Structure. 2004 Sep;12(9):1585-94. PMID:15341724
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