5lwy
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid== | |
| - | + | <StructureSection load='5lwy' size='340' side='right' caption='[[5lwy]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LWY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wxw|3wxw]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lwy OCA], [http://pdbe.org/5lwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lwy RCSB], [http://www.ebi.ac.uk/pdbsum/5lwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lwy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ADR2_HUMAN ADR2_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.<ref>PMID:12802337</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Granier, S]] | ||
| + | [[Category: Leyrat, C]] | ||
| + | [[Category: Vasiliauskaite-Brooks, I]] | ||
| + | [[Category: Ceramidase]] | ||
| + | [[Category: Integral membrane protein]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Progestin and adipoq receptor family]] | ||
Revision as of 16:23, 22 March 2017
Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid
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