5lxg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Revised crystal structure of the human adiponectin receptor 1 in an open conformation== | |
| - | + | <StructureSection load='5lxg' size='340' side='right' caption='[[5lxg]], [[Resolution|resolution]] 2.73Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lxg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wxv|3wxv]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxg OCA], [http://pdbe.org/5lxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxg RCSB], [http://www.ebi.ac.uk/pdbsum/5lxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ADR1_HUMAN ADR1_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.<ref>PMID:12802337</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Granier, S]] | ||
| + | [[Category: Leyrat, C]] | ||
| + | [[Category: Vasiliauskaite-Brooks, I]] | ||
| + | [[Category: Ceramidase]] | ||
| + | [[Category: Integral membrane protein]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Progestin and adipoq receptor family]] | ||
Revision as of 16:23, 22 March 2017
Revised crystal structure of the human adiponectin receptor 1 in an open conformation
| |||||||||||
