1tqx

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|GENE=
|GENE=
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00429 RPE]</span>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00429 RPE]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqx OCA], [http://www.ebi.ac.uk/pdbsum/1tqx PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1tqx RCSB]</span>
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqx OCA], [http://www.ebi.ac.uk/pdbsum/1tqx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tqx RCSB]</span>
}}
}}
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[[Category: tim barrel]]
[[Category: tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:07:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:51 2008''

Revision as of 20:59, 30 March 2008

Image:1tqx.gif


PDB ID 1tqx

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: ,
Domains: RPE
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum


Overview

The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate 3-epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2 A resolution. RPE represents an exciting potential drug target for developing antimalarials because it is involved in the shikimate and the pentose phosphate pathways. The structure is a classic TIM-barrel fold. A coordinated Zn ion and a bound sulfate ion in the active site of the enzyme allow for a greater understanding of the mechanism of action of this enzyme. This structure is solved in the framework of the Structural Genomics of Pathogenic Protozoa (SGPP) consortium.

About this Structure

1TQX is a Single protein structure of sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Reference

Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum., Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG, Proteins. 2006 Feb 1;62(2):338-42. PMID:16304640

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