4x1m
From Proteopedia
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==Structural basis for mutation-induced destabilization of Profilin 1 in ALS== | ==Structural basis for mutation-induced destabilization of Profilin 1 in ALS== | ||
<StructureSection load='4x1m' size='340' side='right' caption='[[4x1m]], [[Resolution|resolution]] 2.17Å' scene=''> | <StructureSection load='4x1m' size='340' side='right' caption='[[4x1m]], [[Resolution|resolution]] 2.17Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4x1m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1M FirstGlance]. <br> | <table><tr><td colspan='2'>[[4x1m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1M FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x1l|4x1l]], [[4x25|4x25]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x1l|4x1l]], [[4x25|4x25]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x1m RCSB], [http://www.ebi.ac.uk/pdbsum/4x1m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1m OCA], [http://pdbe.org/4x1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x1m RCSB], [http://www.ebi.ac.uk/pdbsum/4x1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1m ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PROF1_HUMAN PROF1_HUMAN]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.<ref>PMID:18573880</ref> | [[http://www.uniprot.org/uniprot/PROF1_HUMAN PROF1_HUMAN]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.<ref>PMID:18573880</ref> | ||
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| + | ==See Also== | ||
| + | *[[Profilin|Profilin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:07, 22 March 2017
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
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