Caspase
From Proteopedia
(Difference between revisions)
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**[[3e4c]] – hpro-CASP (mutant) - human<br /> | **[[3e4c]] – hpro-CASP (mutant) - human<br /> | ||
**[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br /> | **[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br /> | ||
| + | **[[5fna]] – hCASP CARD domain – Cryo-EM<br /> | ||
**[[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | **[[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | ||
**[[1sc3]] - hCASP (mutant) + malonate<br /> | **[[1sc3]] - hCASP (mutant) + malonate<br /> | ||
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**[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]], [[4pry]] – hCASP + polypeptide inhibitor<br /> | **[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]], [[4pry]] – hCASP + polypeptide inhibitor<br /> | ||
**[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]], [[4ps0]], [[4ps1]] – hCASP subunits P12, P17 + polypeptide inhibitor<br /> | **[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]], [[4ps0]], [[4ps1]] – hCASP subunits P12, P17 + polypeptide inhibitor<br /> | ||
| - | **[[2dko]], [[2cjx]], [[2cjy]], [[4qtx]], [[4qty]], [[4qu0]], [[4qu5]], [[4qu8]], [[4qu9]], [[4qua]], [[4qub]] [[4qud]], [[4que]], [[4qug]], [[4quh]], [[4qui]], [[4quj]], [[4qul]] - hCASP (mutant) + polypeptide inhibitor<br /> | + | **[[2dko]], [[2cjx]], [[2cjy]], [[4qtx]], [[4qty]], [[4qu0]], [[4qu5]], [[4qu8]], [[4qu9]], [[4qua]], [[4qub]] [[4qud]], [[4que]], [[4qug]], [[4quh]], [[4qui]], [[4quj]], [[4qul]], [[5i9b]], [[5i9t]], [[5iab]], [[5iae]], [[5iag]], [[5iaj]], [[5iak]], [[5ian]], [[5iar]], [[5ias]], [[5ibc]], [[5ibp]], [[5ibr]], [[4qud]] - hCASP (mutant) + polypeptide inhibitor<br /> |
**[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br /> | **[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br /> | ||
**[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br /> | **[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br /> | ||
| + | [[4jqy]], [[4jqz]] - hpro-CASP (mutant)<br /> | ||
**[[1i3o]] - hCASP (mutant) + XIAP-BIR2 | **[[1i3o]] - hCASP (mutant) + XIAP-BIR2 | ||
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*CASP-7 | *CASP-7 | ||
| - | **[[3rk5]], [[ | + | **[[3rk5]], [[4fdl]] - hCASP<br /> |
| - | **[[3ibf]] – hCASP | + | **[[5k20]] – hCASP large + small (mutant) subunits<br /> |
| + | **[[3ibf]] – hCASP large subunit<br /> | ||
**[[3r5k]], [[4hq0]] - hCASP (mutant) <br /> | **[[3r5k]], [[4hq0]] - hCASP (mutant) <br /> | ||
**[[1k86]], [[1gqf]] – hCASP catalytic domain<br /> | **[[1k86]], [[1gqf]] – hCASP catalytic domain<br /> | ||
**[[1k88]] – hpro-CASP (mutant) <br /> | **[[1k88]] – hpro-CASP (mutant) <br /> | ||
| - | **[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP | + | **[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP large subunit + polypeptide inhibitor<br /> |
**[[1f1j]], [[4hqr]] - hCASP + polypeptide inhibitor<br /> | **[[1f1j]], [[4hqr]] - hCASP + polypeptide inhibitor<br /> | ||
**[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br /> | **[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br /> | ||
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**[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br /> | **[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br /> | ||
**[[1i4o]] - hCASP P20 subunit + XIAP<br /> | **[[1i4o]] - hCASP P20 subunit + XIAP<br /> | ||
| - | **[[4jb8]], [[4lsz]] - hCASP | + | **[[4jb8]], [[4lsz]] - hCASP large+small subunits + DARPIN<br /> |
| + | **[[5ic6]], [[5ic4]], [[4zvo]], [[4zvp]], [[4zvq]], [[4zvr]], [[4zvs]], [[4zvt]], [[4zvu]] - hCASP large+small subunits + peptide inhibitor<br /> | ||
*CASP-8 | *CASP-8 | ||
| + | **[[5l08]] – hCASP – Cryo-EM<br /> | ||
| + | **[[4zbw]] - hCASP death effector domain<br /> | ||
**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | **[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | ||
**[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | **[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | ||
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**[[1jxq]] - hCASP + polypeptide inhibitor<br /> | **[[1jxq]] - hCASP + polypeptide inhibitor<br /> | ||
**[[3v3k]] – hCASP + effector protein<br /> | **[[3v3k]] – hCASP + effector protein<br /> | ||
| + | **[[5wve]], [[5juy]] – hCASP CARD domain + APAF-1<br /> | ||
**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | **[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | ||
**[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD | **[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD | ||
Revision as of 09:12, 28 March 2017
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3D structures of caspase
Updated on 28-March-2017
4jqy, 4jqz - hpro-CASP (mutant)
References
- ↑ Schweizer A, Briand C, Grutter MG. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem. 2003 Oct 24;278(43):42441-7. Epub 2003 Aug 14. PMID:12920126 doi:http://dx.doi.org/10.1074/jbc.M304895200
- ↑ Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al.. Structure and mechanism of interleukin-1 beta converting enzyme. Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875 doi:http://dx.doi.org/10.1038/370270a0
