5n1u
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1u OCA], [http://pdbe.org/5n1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1u RCSB], [http://www.ebi.ac.uk/pdbsum/5n1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1u OCA], [http://pdbe.org/5n1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1u RCSB], [http://www.ebi.ac.uk/pdbsum/5n1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Sister-chromatid cohesion is established by Eco1-mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit. However, the molecular basis of Eco1 substrate recognition and acetylation in cohesion is not fully understood. Here, we discover and rationalize the substrate specificity of Eco1 using mass spectrometry coupled with in-vitro acetylation assays and crystallography. Our structures of the X. laevis Eco2 (xEco2) bound to its primary and secondary Smc3 substrates demonstrate the plasticity of the substrate-binding site, which confers substrate specificity by concerted conformational changes of the central beta hairpin and the C-terminal extension. | ||
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| + | Structural Basis of Eco1-Mediated Cohesin Acetylation.,Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR Sci Rep. 2017 Mar 14;7:44313. doi: 10.1038/srep44313. PMID:28290497<ref>PMID:28290497</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5n1u" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:50, 29 March 2017
Structure of xEco2 acetyltransferase domain
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