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5uvf

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'''Unreleased structure'''
 
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The entry 5uvf is ON HOLD
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==Crystal Structure of the Human vaccinia-related kinase bound to BI-D1870==
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<StructureSection load='5uvf' size='340' side='right' caption='[[5uvf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Counago, R.M., Bountra, C., Arruda, P., Edwards, A.M., Gileadi, O., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5uvf]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5uge 5uge]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UVF FirstGlance]. <br>
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Description: Crystal Structure of the Human vaccinia-related kinase bound to BI-D1870
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7DZ:(7S)-2-[(3,5-DIFLUORO-4-HYDROXYPHENYL)AMINO]-5,7-DIMETHYL-8-(3-METHYLBUTYL)-7,8-DIHYDROPTERIDIN-6(5H)-ONE'>7DZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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[[Category: Counago, R.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvf OCA], [http://pdbe.org/5uvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uvf RCSB], [http://www.ebi.ac.uk/pdbsum/5uvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvf ProSAT]</span></td></tr>
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[[Category: Edwards, A.M]]
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</table>
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[[Category: Gileadi, O]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arruda, P]]
[[Category: Arruda, P]]
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[[Category: Structural Genomics Consortium (Sgc)]]
 
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Counago, R M]]
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[[Category: Edwards, A M]]
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[[Category: Gileadi, O]]
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[[Category: Structural genomic]]
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[[Category: Protein kinase domain]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 06:56, 29 March 2017

Crystal Structure of the Human vaccinia-related kinase bound to BI-D1870

5uvf, resolution 2.00Å

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