This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5gk9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5gk9 is ON HOLD until Paper Publication
+
==Crystal structure of human HBO1 in complex with BRPF2==
-
 
+
<StructureSection load='5gk9' size='340' side='right' caption='[[5gk9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
Authors: Tao, Y., Zhu, J., Xu, S., Ding, J.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5gk9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GK9 FirstGlance]. <br>
-
Description: Crystal structure of a new HAT complex
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gk9 OCA], [http://pdbe.org/5gk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gk9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/KAT7_HUMAN KAT7_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.<ref>PMID:10438470</ref> <ref>PMID:10930412</ref> <ref>PMID:11278932</ref> <ref>PMID:16387653</ref> <ref>PMID:18832067</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Histone acetyltransferase]]
[[Category: Ding, J]]
[[Category: Ding, J]]
 +
[[Category: Tao, Y]]
 +
[[Category: Xu, S]]
[[Category: Zhu, J]]
[[Category: Zhu, J]]
-
[[Category: Xu, S]]
+
[[Category: Hat]]
-
[[Category: Tao, Y]]
+
[[Category: Transferase-metal binding protein complex]]

Revision as of 13:42, 29 March 2017

Crystal structure of human HBO1 in complex with BRPF2

5gk9, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5gk9"
Personal tools