5ipz

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'''Unreleased structure'''
 
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The entry 5ipz is ON HOLD until Paper Publication
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==Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide==
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<StructureSection load='5ipz' size='340' side='right' caption='[[5ipz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Smirnov, A., Manakova, E., Grazulis, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ipz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IPZ FirstGlance]. <br>
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Description: Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CC:5-(2-AMINO-1,3-THIAZOL-4-YL)-2-CHLOROBENZENE-1-SULFONAMIDE'>6CC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ipz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipz OCA], [http://pdbe.org/5ipz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ipz RCSB], [http://www.ebi.ac.uk/pdbsum/5ipz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipz ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[http://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Carbonate dehydratase]]
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[[Category: Grazulis, S]]
[[Category: Manakova, E]]
[[Category: Manakova, E]]
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[[Category: Grazulis, S]]
 
[[Category: Smirnov, A]]
[[Category: Smirnov, A]]
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[[Category: Benzenesulfonamide]]
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[[Category: Carbonic anhydrase]]
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[[Category: Drug design]]
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[[Category: Lyase]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Metal-binding]]

Revision as of 13:43, 29 March 2017

Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide

5ipz, resolution 2.10Å

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