5m7r
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human O-GlcNAc hydrolase== | |
| - | + | <StructureSection load='5m7r' size='340' side='right' caption='[[5m7r]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5m7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M7R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7r OCA], [http://pdbe.org/5m7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7r RCSB], [http://www.ebi.ac.uk/pdbsum/5m7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7r ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Britton, R]] | ||
| + | [[Category: Chan, S]] | ||
| + | [[Category: Davies, G J]] | ||
| + | [[Category: Hemsworth, G R]] | ||
| + | [[Category: King, D]] | ||
| + | [[Category: Offen, W A]] | ||
| + | [[Category: Roth, C]] | ||
| + | [[Category: Varghese, V]] | ||
| + | [[Category: Vocadlo, D J]] | ||
| + | [[Category: Willems, L I]] | ||
| + | [[Category: Human glacoside hydrolase glcnac]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 13:46, 29 March 2017
Structure of human O-GlcNAc hydrolase
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