5mu8
From Proteopedia
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| - | ''' | + | {{Large structure}} |
| + | ==HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525== | ||
| + | <StructureSection load='5mu8' size='340' side='right' caption='[[5mu8]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5mu8]] is a 48 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MU8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JNI:~{N}4-(PHENYLMETHYL)-~{N}4-[2-[3-(2-PIPERAZIN-1-YLPYRIMIDIN-5-YL)PHENYL]PHENYL]PYRIMIDINE-2,4-DIAMINE'>JNI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu8 OCA], [http://pdbe.org/5mu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu8 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | {{Large structure}} | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref> The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A prevalent observation in high-throughput screening and drug discovery programs is the inhibition of protein function by small-molecule compound aggregation. Here, we present the X-ray structural description of aggregation-based inhibition of a protein-protein interaction involving tumor necrosis factor alpha (TNFalpha). An ordered conglomerate of an aggregating small-molecule inhibitor (JNJ525) induces a quaternary structure switch of TNFalpha that inhibits the protein-protein interaction between TNFalpha and TNFalpha receptors. SPD-304 may employ a similar mechanism of inhibition. | ||
| - | + | Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.,Blevitt JM, Hack MD, Herman KL, Jackson PF, Krawczuk PJ, Lebsack AD, Liu AX, Mirzadegan T, Nelen MI, Patrick AN, Steinbacher S, Milla ME, Lumb KJ J Med Chem. 2017 Mar 16. PMID:28300404<ref>PMID:28300404</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5mu8" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Blevitt, J M]] | ||
| + | [[Category: Hack, M D]] | ||
| + | [[Category: Herman, K L]] | ||
| + | [[Category: Jackson, P F]] | ||
| + | [[Category: Krawczuk, P J]] | ||
| + | [[Category: Lebsack, A D]] | ||
| + | [[Category: Liu, A X]] | ||
| + | [[Category: Lumb, K J]] | ||
| + | [[Category: Milla, M E]] | ||
| + | [[Category: Mirzadegan, T]] | ||
| + | [[Category: Nelen, M I]] | ||
| + | [[Category: Patrick, A P]] | ||
| + | [[Category: Steinbacher, S]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Proteros biostructures gmbh]] | ||
| + | [[Category: Tumor necrosis factor alpha]] | ||
Revision as of 13:47, 29 March 2017
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HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525
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