Sandbox Reserved 1243

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
==L-PGDS==
==L-PGDS==
<StructureSection load='2CZU' size='340' side='right' caption='Lipocalin-type Prostaglandin D Synthase' scene='Me'>
<StructureSection load='2CZU' size='340' side='right' caption='Lipocalin-type Prostaglandin D Synthase' scene='Me'>
-
This is a default text for your page OOOGA BOOGA WAWA KABLOOEY!''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
+
Lipocalin-type Prostaglandin D Synthase (L-PGDS) is the second most abundant protein
 +
in the human cerebrospinal fluid. It is involved in the transport of hydrophobic molecules
 +
as well as its namesake in the production of prostaglandin D2: an unsaturated fatty acid
 +
that is involved in maintaining homeostasis, regulating sleep, aiding in inflammatory
 +
responses, and other neurological functions. Although structurally and biochemically
 +
different from hematopoietic-PGD synthase, they both take part in the arachidonate
 +
cyclooxygenase pathway to make PGD from PGH2. The smaller of the two PGD
 +
synthases, L-PGDS contains a beta-barrel structure and was initially found in the brain. It
 +
was later found in the tissues of the heart, kidneys, and lungs as well as a number of other
 +
body fluids. Inhibiting this enzyme results in the deterioration and lack of function of
 +
major organs and metabolic processes and has been found to be linked to some cancers,
 +
hair loss, and diabetes. L-PGDS can trigger both pro- and anti-inflammatory responses to
 +
the immune system, allowing its levels to be highly regulated.
 +
 
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>doi:10.1155/2012/503128</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>doi:10.1155/2012/503128</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

Revision as of 19:20, 29 March 2017

This Sandbox is Reserved from Jan 17 through June 31, 2017 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, USA. This reservation includes Sandbox Reserved 1225 through Sandbox Reserved 1244.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

L-PGDS

Lipocalin-type Prostaglandin D Synthase

Drag the structure with the mouse to rotate

References

  1. ↑ Joo M, Sadikot RT. PGD synthase and PGD2 in immune resposne. Mediators Inflamm. 2012;2012:503128. doi: 10.1155/2012/503128. Epub 2012 Jun 25. PMID:22791937 doi:http://dx.doi.org/10.1155/2012/503128
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1243"
Personal tools