Sandbox Reserved 1231
From Proteopedia
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{{Sandbox_Reserved_Jason_Telford}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_Jason_Telford}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| - | == | + | ==Titin Structure== |
| - | + | Titin is a giant sarcomeric protein that is found in both cardiac and skeletal muscle. Since this protein extends from the Z-line to the M-line, this protein plays a crucial role in the maintenance of the sarcomere structural integrity and it also plays a role as a shock absorber in sarcomeres. Titin essentially regulates the sarcomeric length and performs adequate adjustments of passive tension when the length varies. When the Titin is stretched the thermal disturbances are expecting it to follow the Maxwell path (global minimizer of its energy which doesn't involve energy dissipation or hysteresis. This path involves a barrier crossing at the transitions and overcoming this barrier will cause disturbances. | |
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== Function == | == Function == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | Castro-Ferreira, Ricardo, and Ricardo Fontes-Carvalho. "SciFinder." The role of titin in the modulation of cardiac function and its pathophysiological implications. Sociedade Brasileira De Cardiologia, n.d. Web. 13 Feb. 2017. | ||
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| + | Benichou, Tamar, and Sefi Givli. The hidden ingenuity in titin structure. American Institute of Physics, n.d. Web. 13 Feb. 2017. | ||
Revision as of 19:46, 29 March 2017
| This Sandbox is Reserved from Jan 17 through June 31, 2017 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, USA. This reservation includes Sandbox Reserved 1225 through Sandbox Reserved 1244. |
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Contents |
Titin Structure
Titin is a giant sarcomeric protein that is found in both cardiac and skeletal muscle. Since this protein extends from the Z-line to the M-line, this protein plays a crucial role in the maintenance of the sarcomere structural integrity and it also plays a role as a shock absorber in sarcomeres. Titin essentially regulates the sarcomeric length and performs adequate adjustments of passive tension when the length varies. When the Titin is stretched the thermal disturbances are expecting it to follow the Maxwell path (global minimizer of its energy which doesn't involve energy dissipation or hysteresis. This path involves a barrier crossing at the transitions and overcoming this barrier will cause disturbances.
Function
The primary function of Titin is to stabilize the thick filaments by centering between the thin filaments. It also prevents the sarcomere from over-stretching by recoiling the sarcomere like a spring.
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
References
Castro-Ferreira, Ricardo, and Ricardo Fontes-Carvalho. "SciFinder." The role of titin in the modulation of cardiac function and its pathophysiological implications. Sociedade Brasileira De Cardiologia, n.d. Web. 13 Feb. 2017.
Benichou, Tamar, and Sefi Givli. The hidden ingenuity in titin structure. American Institute of Physics, n.d. Web. 13 Feb. 2017.
