1tz6
From Proteopedia
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|PDB= 1tz6 |SIZE=350|CAPTION= <scene name='initialview01'>1tz6</scene>, resolution 2.70Å | |PDB= 1tz6 |SIZE=350|CAPTION= <scene name='initialview01'>1tz6</scene>, resolution 2.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=AIS:5-AMINOIMIDAZOLE+RIBONUCLEOSIDE'>AIS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Fructokinase Fructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.4 2.7.1.4] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructokinase Fructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.4 2.7.1.4] </span> |
|GENE= Stm4066 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella typhimurium LT2]) | |GENE= Stm4066 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella typhimurium LT2]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1tyy|1TYY]], [[1tz3|1TZ3]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tz6 OCA], [http://www.ebi.ac.uk/pdbsum/1tz6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tz6 RCSB]</span> | ||
}} | }} | ||
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[[Category: Ealick, S E.]] | [[Category: Ealick, S E.]] | ||
[[Category: Zhang, Y.]] | [[Category: Zhang, Y.]] | ||
| - | [[Category: ACP]] | ||
| - | [[Category: AIS]] | ||
| - | [[Category: K]] | ||
| - | [[Category: MG]] | ||
[[Category: alpha/beta]] | [[Category: alpha/beta]] | ||
[[Category: ribokinase fold]] | [[Category: ribokinase fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:13 2008'' |
Revision as of 21:03, 30 March 2008
| |||||||
| , resolution 2.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | Stm4066 (Salmonella typhimurium LT2) | ||||||
| Activity: | Fructokinase, with EC number 2.7.1.4 | ||||||
| Related: | 1TYY, 1TZ3
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of aminoimidazole riboside kinase from Salmonella enterica complexed with aminoimidazole riboside and ATP analog
Overview
The crystal structures of a Salmonella enterica aminoimidazole riboside (AIRs) kinase, its complex with the substrate AIRs, and its complex with AIRs and an ATP analog were determined at 2.6 angstroms, 2.9 angstroms, and 2.7 angstroms, respectively. The product of the Salmonella-specific gene stm4066, AIRs kinase, is a homodimer with one active site per monomer. The core structure, consisting of an eight-stranded beta sheet flanked by eight alpha helices, indicates that AIRs kinase is a member of the ribokinase superfamily. Unlike ribokinase and adenosine kinase in this superfamily, AIRs kinase does not show significant conformational changes upon substrate binding. The active site is covered by a lid formed by residues 16-28 and 86-100. A comparison of the structure of AIRs kinase with other ribokinase superfamily members suggests that the active site lid and conformational changes that occur upon substrate binding may be advanced features in the evolution of the ribokinase superfamily.
About this Structure
1TZ6 is a Single protein structure of sequence from Salmonella typhimurium lt2. Full crystallographic information is available from OCA.
Reference
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:15458630
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