User:Luke Edward Severinac/Sandbox 1
From Proteopedia
(Difference between revisions)
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==Active Site== | ==Active Site== | ||
Caspase 6 is a part of the cystine aspartase family that cleaves proteins at the TEVD sequence. in its monomeric form with protein ligand bound, its catalytic residues are <scene name='75/752344/His121/1'>Histidine 121</scene>, <scene name='75/752344/Glu123/1'>Glutamate 123</scene>, and <scene name='75/752344/Cys163/1'>Cystine 163</scene>.[[Image:Mechanism caspase 6.PNG|100 px|left|thumb|Cystine Aspartase mechanism]] Together, these residues form a <scene name='75/752344/Caspase-6_catalytic_triad_real/1'>catalytic triad</scene> that cleaves <scene name='75/752344/Protein_ligand/1'>protein ligands</scene>. | Caspase 6 is a part of the cystine aspartase family that cleaves proteins at the TEVD sequence. in its monomeric form with protein ligand bound, its catalytic residues are <scene name='75/752344/His121/1'>Histidine 121</scene>, <scene name='75/752344/Glu123/1'>Glutamate 123</scene>, and <scene name='75/752344/Cys163/1'>Cystine 163</scene>.[[Image:Mechanism caspase 6.PNG|100 px|left|thumb|Cystine Aspartase mechanism]] Together, these residues form a <scene name='75/752344/Caspase-6_catalytic_triad_real/1'>catalytic triad</scene> that cleaves <scene name='75/752344/Protein_ligand/1'>protein ligands</scene>. | ||
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If <scene name='75/752344/Serine_257_highlighted/1'>Serine 257</scene> is <scene name='pdbligand=PO4:PHOSPHATE+ION'>Phospohrylated</scene> , the activity of this protein is inhibited. | If <scene name='75/752344/Serine_257_highlighted/1'>Serine 257</scene> is <scene name='pdbligand=PO4:PHOSPHATE+ION'>Phospohrylated</scene> , the activity of this protein is inhibited. | ||
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<scene name='75/752344/Uncleaved_caspase_6/1'>inactive caspase</scene> | <scene name='75/752344/Uncleaved_caspase_6/1'>inactive caspase</scene> | ||
| - | ==Catalytic triad== | ||
| - | <scene name='75/752344/Caspase-6_catalytic_triad/2'>catalytic triad</scene> | ||
== Relevance == | == Relevance == | ||
Revision as of 00:51, 2 April 2017
Caspase 6 in Homo Sapiens
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966951/ (self cleavage article)
http://www.rcsb.org/pdb/explore/explore.do?structureId=2WDP (this is the non-self cleaved protien)
