User:Luke Edward Severinac/Sandbox 1
From Proteopedia
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==Caspase 6 in ''Homo Sapiens''== | ==Caspase 6 in ''Homo Sapiens''== | ||
| - | <StructureSection load='4FXO' size='340' side='right' caption='This is the 3D PDB protein that was presented in class, 4FXO. (Caspase-6)' scene=''> | + | <StructureSection load='4FXO' size='340' side='right' caption='This is the 3D PDB protein that was presented in class, 4FXO. (Caspase-6)' scene=''> |
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
[[Image:4FXO.PNG|100 px|left|thumb|This is the figure legend of the thumbnail]] | [[Image:4FXO.PNG|100 px|left|thumb|This is the figure legend of the thumbnail]] | ||
| + | =='''Function'''== | ||
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=='''Structure'''== | =='''Structure'''== | ||
| - | ==Active Site== | + | ===Active Site=== |
Caspase 6 is a part of the cystine aspartic protease family that cleaves proteins at the TEVD sequence. in its monomeric form with protein ligand bound, its catalytic residues are <scene name='75/752344/His121/1'>Histidine 121</scene>, <scene name='75/752344/Glu123/1'>Glutamate 123</scene>, and <scene name='75/752344/Cys163/1'>Cystine 163</scene>.[[Image:Mechanism caspase 6.PNG|100 px|left|thumb|Cystine Aspartase mechanism]] Together, these residues form a <scene name='75/752344/Caspase-6_catalytic_triad_real/1'>catalytic triad</scene> that cleaves a <scene name='75/752344/Protein_ligand/1'>protein ligand</scene>. | Caspase 6 is a part of the cystine aspartic protease family that cleaves proteins at the TEVD sequence. in its monomeric form with protein ligand bound, its catalytic residues are <scene name='75/752344/His121/1'>Histidine 121</scene>, <scene name='75/752344/Glu123/1'>Glutamate 123</scene>, and <scene name='75/752344/Cys163/1'>Cystine 163</scene>.[[Image:Mechanism caspase 6.PNG|100 px|left|thumb|Cystine Aspartase mechanism]] Together, these residues form a <scene name='75/752344/Caspase-6_catalytic_triad_real/1'>catalytic triad</scene> that cleaves a <scene name='75/752344/Protein_ligand/1'>protein ligand</scene>. | ||
| + | ===Zinc Exoside=== | ||
| + | ==Inhbition== | ||
| + | ===Zinc Inhibition=== | ||
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| + | ===Phosphoylation=== | ||
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| + | ==Luke's free space== | ||
If <scene name='75/752344/Serine_257_highlighted/1'>Serine 257</scene> is <scene name='pdbligand=PO4:PHOSPHATE+ION'>Phospohrylated</scene> , the activity of this protein is inhibited. | If <scene name='75/752344/Serine_257_highlighted/1'>Serine 257</scene> is <scene name='pdbligand=PO4:PHOSPHATE+ION'>Phospohrylated</scene> , the activity of this protein is inhibited. | ||
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== Relevance == | == Relevance == | ||
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| - | == Structural highlights == | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 01:04, 2 April 2017
Caspase 6 in Homo Sapiens
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966951/ (self cleavage article)
http://www.rcsb.org/pdb/explore/explore.do?structureId=2WDP (this is the non-self cleaved protien)
