Topoisomerase binding protein
From Proteopedia
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| - | <StructureSection load='3ueo' size='450' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (PDB entry [[3ueo]])' scene='56/564070/Cv/ | + | <StructureSection load='3ueo' size='450' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (PDB entry [[3ueo]])' scene='56/564070/Cv/4'> |
== Function == | == Function == | ||
'''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. | '''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides. The phospho-peptide interacts with BRCT4 and BRCT5 | + | TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides. The <scene name='56/564070/Cv/3'>phospho-peptide interacts with BRCT4 and BRCT5 of both monomers</scene><ref>PMID:23891287</ref>. |
==3D structures of topoisomerase binding protein== | ==3D structures of topoisomerase binding protein== | ||
Revision as of 09:08, 2 April 2017
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