User:Luke Edward Severinac/Sandbox 1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 41: Line 41:
If <scene name='75/752344/Serine_257_highlighted/1'>Serine 257</scene> is <scene name='pdbligand=PO4:PHOSPHATE+ION'>Phospohrylated</scene> , the activity of this protein is inhibited.
If <scene name='75/752344/Serine_257_highlighted/1'>Serine 257</scene> is <scene name='pdbligand=PO4:PHOSPHATE+ION'>Phospohrylated</scene> , the activity of this protein is inhibited.
-
 
+
[[Image:Caspase 6 sequence image.JPG]]
If <scene name='pdbligand=ZN:ZINC+ION'>Zinc</scene> binds to the protein, the activity of the active site is inhibited.
If <scene name='pdbligand=ZN:ZINC+ION'>Zinc</scene> binds to the protein, the activity of the active site is inhibited.

Revision as of 23:30, 2 April 2017

Caspase-6 in Homo sapiens

Caspase-6

Drag the structure with the mouse to rotate

References

  1. Velazquez-Delgado EM, Hardy JA. Zinc-Mediated Allosteric Inhibition of Caspase-6. J Biol Chem. 2012 Aug 13. PMID:22891250 doi:http://dx.doi.org/10.1074/jbc.M112.397752

Wang, Xiao-Jun, Qin Cao, Yan Zhang, and Xiao-Dong Su. "Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases." Annual Review of Pharmacology and Toxicology 55.1 (2015): 553-72. Web.

Wang XJ, Cao Q, Liu X, Wang KT, Mi W, et al. 2010. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. EMBO Rep. 11: 841–47

(self cleavage article)

http://www.rcsb.org/pdb/explore/explore.do?structureId=2WDP (this is the non-self cleaved protien)

Proteopedia Page Contributors and Editors (what is this?)

Luke Edward Severinac

Personal tools